When I was researching my update, general consensus seemed to be to avoid the mids behind the seats as without a DSP to manage the frequency response, you end up with an odd sound stage and buzzing bass. Much better to focus your budget on the front components (2 or 3 way) and then add more bass if required, either in the cubbys, or in a stand alone box. The rear mids are also a pain to get to as you have to take the whole rear bulk-head trim apart.
As far as I'm aware, there aren't any direct fit 'plug and play' for the E85 mids (front or behind seats), or off the shelf adaptors, so you will need to apply some ingenuity regardless of what you choose
No brackets or adaptations required to fit the 6.5" focal components in the kick panels - not sure if this would hold for other brands. The original speaker screws hold them perfectly adequately.