I might be corrected by someone more knowledgeable than me, but I would think the longevity of an engine is not so much dependant how many miles it has done, but the nature of the miles. I.e. how many of those miles was the engine below temperature? I would think that a well lubricated engine that spends 99.5% of it's times at full temp will not wear away for a very long time. I would think it might be useful for cars to be advertised with details of, alongside total mileage, number of cold starts and/or miles below normal operating temp. That 200k sales rep Volvo might start to become more appealing than the one with one lady owner and 60k miles.
Of course everything will wear out eventually, but I've never had the engine itself fail on a car, and this includes poorly-looked-after Vauxhalls that have done mostly short journeys approaching 150k miles. I have however scrapped many vehicles (I think I was on to my tenth car before I actually sold one) and it's generally been due to either rust (less of an issue on more modern cars, and as much about age as mileage to a certain degree) or things like gaskets or wheel bearings etc costing £500 to replace when the car was worth £400 - off to the scrapyard and then back onto ebay for the next glorious machine.
That brings you onto the idea of "uneconomical repair", and that is subjective and depends what your long term plans are for the car. If you want to sell it at some point then that's more of a problem. I think some people look at it that way when deciding whether a repair is economical or not, but what they're really working out is what is the cheapest course of action in the very short term, with a dash of subconscious "I'd quite like a new car" - e.g. £1,500 to repair it, or £2,500 to replace the whole car. That's when it gets scrapped. Unfortunately that next car will probably need something similar soon as well...
I currently have a Yeti that is on 109k miles (25k in the last year). It drives just as well as it did a year ago on 84k miles, and has now had the cambelt replaced, new upgraded discs and pads all round, upgraded front calipers, upgraded wheels, new tyres, new steering wheel, air con fixed and a good clean. On the used car market, due to the mileage, it is worth 25% less than it was when I bought it. But it should arguably be worth more, objectively, because there are fewer things that will need doing in the next year compared to the last. The question of the engine itself wearing out is probably at least 100k miles away still, so barely relevant. If the turbo goes next week and costs £1k to replace (or £2k for a bigger one!) then many people would take it to the scrapyard - you'd be crazy to spend £1k on fixing a car that's worth £3.5k, wouldn't you? But it'll cost a hell of a lot more to trade it in for a lower mileage one, on which the turbo is just as likely to go 12 months later.
I just don't see "engine death" as being a realistic worry anywhere near 100k miles in 99% of modern cars. The biggest question for me, if looking at a higher mileage car, would be what has been replaced (from the list of things that will need doing at some point). Depending on the answer, the 100k mile car could be a better prospect than one on 60k for the same price (ignoring resale value).
Bit of a ramble there, apologies...